Which work is attributed to John Milton?

John Milton is famously known for his prose and poetry that are deeply engaged with themes of freedom, governance, and the human condition. "Areopagitica," one of his most celebrated works, is a passionate plea for the freedom of the press and opposition to censorship. Written in 1644, it argues against the licensing of publications, asserting that the truth will ultimately prevail if left to the market of ideas. This work not only exemplifies Milton's eloquent advocacy for individual liberties but also reflects the Enlightenment ideals of the period.

While the other titles listed are associated with important literary figures, they do not originate from Milton. "Novum Organum" is a philosophical work by Francis Bacon, exploring scientific methodology. "Mac Flecknoe" is a mock-heroic poem by John Dryden that satirizes the poet Thomas Shadwell. "The Vine" does not have a clear attribution to a prominent author and is not recognized as a major work in literary history. Hence, "Areopagitica" stands out as the correct choice due to its clear authorship by John Milton.